Abstract
To determine the effect of flunarizine therapy on patients with alternating hemiplegia
of childhood (AHC), we sent a questionnaire by mail to council members of the Japanese
Society of Child Neurology. We collected 28 AHC patients, and studied their clinical
courses and the effects of drug therapy. All of the patients had received flunarizine.
In 18 of the 28 patients, flunarizine reduced the severity, duration, or frequency
of the hemiplegic attacks. No other drug was more effective than flunarizine. Some
flunarizine non-effective patients were severely deteriorated, for example, they had
dementia or were ventilator-assisted. Flunarizine had not only a short-term effect,
i.e. it reduced the hemiplegic attacks, but also a long-term effect on the motor and
intellectual development in some patients with AHC. Flunarizine is still an essential
drug for treating AHC.
Keywords
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References
- Alternating hemiplegia in childhood: a report of eight patients with complicated migraine beginning in infancy.Pediatrics. 1971; 47: 675-680
- Alternating hemiplegia in infants: report of five cases.Dev Med Child Neurol. 1980; 22: 784-791
- Evidence for mitochondrial dysfunction in patients with alternating hemiplegia of childhood.Ann Neurol. 1993; 33: 604-607
- Skeletal muscle mitochondrial dysfunction in alternating hemiplegia of childhood.Ann Neurol. 1995; 38: 681-684
- Flunarizine in alternating hemiplegia in childhood.Lancet. 1984; 2: 579
- Flunarizine in alternating hemiplegia in childhood. An international study in 12 children.Neuropediatrics. 1987; 18: 191-195
- Alternating hemiplegia of childhood: a study of 10 patients and results of flunarizine treatment.Neurology. 1993; 43: 36-41
- Alternating hemiplegia of childhood.J Pediatr. 1993; 122: 673-679
- Alternating hemiplegia in childhood: 23 cases in Japan.Brain Dev. 1992; 14: 283-288
- Successful trial of amantadine hydrochloride for two patients with alternating hemiplegia of childhood.Neuropediatrics. 2001; (in press)
- Is infantile alternating hemiplegia mediated by glutamate toxicity and can it be treated with memantine?.Neuropediatrics. 1996; 27: 277-278
- Alternating hemiplegia of childhood: clinical manifestations and long-term outcome.Pediatr Neurol. 2000; 23: 134-141
- Alternating hemiplegia of childhood: insights into its pathophysiology.J Child Neurol. 1998; 13: 39-45
- Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ gene CACNL1A4.Cell. 1996; 87: 543-552
Article Info
Publication History
Accepted:
April 26,
2001
Received in revised form:
April 13,
2001
Received:
February 9,
2001
Identification
Copyright
© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
