Advertisement
Case report| Volume 23, ISSUE 4, P264-268, July 2001

Download started.

Ok

Epileptic seizures and structural abnormalities in a patient with holoprosencephaly

      Abstract

      In a patient with holoprosencephaly, partial seizures had various initial ictal symptoms, and ictal EEGs showed epileptogenic foci in the right and left brain. Partial seizures did not culminate in secondary generalized tonic–clonic convulsions. Characteristic malformed structures contribute to the absence of secondary generalization and the presence of Jacksonian-type propagation.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Kundrat H.
        Arhinencephalie als typische Art von Missbildung. Graz von Leuschner and Lubensky.
        Wien Med Bl. 1882; 5: 1395
        • DeMyer W.
        • White P.T.
        EEG in holoprosencephaly (arhinencephaly).
        Arch Neurol. 1964; 11: 507-520
        • Roessler E.
        • Belloni E.
        • Gaudenz K.
        • Jay P.
        • Berta P.
        • Scherer S.W.
        • et al.
        Mutations in the human sonic hedgehog gene cause holoprosencephaly.
        Nat Genet. 1996; 14: 357-360
        • Seki Y.
        • Kumagai K.
        • Goto N.
        Holoprosencephaly.
        J Kanazawa Med Univ. 1978; 3: 117-125
        • Akimoto H.
        • Takemine H.
        • Okutani A.
        • Funabiki N.
        • Ito H.
        Two cases of holoprosencephaly.
        Shounika Shinryou. 1970; 33: 1507-1513
        • Chugani H.T.
        • Shewmon D.A.
        • Shields W.D.
        • Sankar R.
        • Comair Y.
        • Vinters H.V.
        • et al.
        Surgery for intractable infantile spasms: neuroimaging perspectives.
        Epilepsia. 1993; 34: 764-771
        • Erickson T.C.
        Spread of the epileptic discharge; an experimental study of the after-discharge induced by electrical stimulation of the cerebral cortex.
        Arch Neurol Psychiatry. 1940; 43: 429-452
        • Wilder B.J.
        • Schmidt R.P.
        Propagation of epileptic discharge from chronic neocortical foci in monkey.
        Epilepsia. 1965; 6: 297-309
        • Gobbi G.
        • Parmeggiani A.
        • Pini A.
        • Tassinari C.A.
        Periodic spasms: a particular type of infantile spasms.
        N Trends Pediatr Epileptol. 1991; : 111-118
        • Yamamoto N.
        • Watanabe K.
        • Negoro T.
        • Furune S.
        • Takahashi I.
        • Nomura K.
        • et al.
        Partial seizures evolving to infantile spasms.
        Epilepsia. 1988; 29: 34-40