Original article| Volume 23, ISSUE 4, P223-227, July 2001

The role of Glial–Pial barrier lesions and impaired vascularization in anomalous formation of cortical convolutions


      The abnormal patterns of cerebral convolutions range from severe to small anomalies restricted to tertiary gyri and sulci. Lesions within Glial–Pial barrier were found in examined cases with cortical developmental abnormalities. Anomalies and impaired function of vessels penetrating the cortex from meningeal plexus coexisted often with Glial–Pial barrier lesions. We are able to say that our cases constitute a group of graded changes demonstrating that both observed developmental lesions vascular and/or Glial–Pial barrier damage may result in cortical anomalies. Their formation and character depend on the stage of cortical maturation when analyzed lesions occur.


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        • Choi B.H.
        • Matthias S.C.
        Cortical dysplasia associated with massive ectopia of neurons and glial cells within the subarachnoid space.
        Acta Neuropathol(Berl). 1987; 73: 105-109
        • Norman M.G.
        • McGillivray B.C.
        • Kalousek D.K.
        • Hill A.
        • Poskitt K.J.
        Congenital malformations of the brain. Oxford University Press, New York, Oxford1995
        • Kuzniecky R.I.
        Magnetic resonance imaging in developmental disorders of the cerebral cortex.
        Epilepsia. 1994; 35: S44-S56
        • Kuzniecky R.
        • Garcia J.H.
        • Faught E.
        • Morawetz R.B.
        Cortical dysplasia in temporal lobe epilepsy: magnetic resonance imaging correlations.
        Ann Neurol. 1991; 29: 293-298
        • Wisniewski K.E.
        • Dąmbska M.
        Correlations between clinical and neuropathological diagnosis of cortical anomalies in developmentally disabled children.
        Brain Dev. 1995; 17: 48-54
        • Shimada M.
        [Chaos in pathogenesis of brain dysgenesis](in Japanese).
        No To Hattatsu. 1996; 28: 93-101
        • Dambska M.
        • Wiśniewski K.E.
        Normal and pathologic development of the human brain and spinal cord. John Libbey, London1999: 47-51
        • Ferrer I.
        A Golgi analysis of unlayered polymicrogyria.
        Acta Neuropathol (Berl). 1984; 65: 69-76
        • Dąmbska M.
        • Wiśniewski K.E.
        • Sher J.H.
        Lissencephaly: two distinct clinico-pathological types.
        Brain Dev. 1983; 5: 302-310
        • Squier M.V.
        Fetal type II lissencephaly: a case report.
        Childs Nerv Syst. 1993; 9: 400-402
        • Yamamoto T.
        • Toyoda C.
        • Kobayashi M.
        • Kondo E.
        • Saito K.
        • Osawa M.
        Pial-glial barrier abnormalities in fetuses with Fukuyama congenital muscular dystrophy.
        Brain Dev. 1997; 19: 35-42
        • Norman M.G.
        • Roberts M.
        • Sirois J.
        • Tremblay L.J.
        Can J Neurol Sci. 1976; 3: 39-46
        • Dąmbska M.
        • Wiśniewski K.E.
        • Sher J.H.
        Marginal glioneuronal heterotopias in nine cases with and without cortical abnormalities.
        J Child Neurol. 1986; 1: 149-157
        • Kuchna I.
        • Iwanowski L.
        • Dambska M.
        Vascular malformations associated with other congenital anomalies of the central nervous system: coexistence and possible causal relations.
        Folia Neuropathol. 1995; 33: 255-259
        • Dvorak K.
        • Feit J.
        Migration of neuroblasts through partial necrosis of the cerebral cortex in newborn rats-contribution to the problems of morphological development and developmental period of cerebral microgyria. Histological and autoradiographical study.
        Acta Neuropathol (Berl). 1977; 38: 203-212
        • Dvorak K.
        • Feit J.
        • Jurankova Z.
        Experimentally induced focal microgyria and status verrucosus deformis in rats: pathogenesis and interrelations. Histological and autoradiographical study.
        Acta Neuropathol (Berl). 1978; 44: 121-129
        • Kuban K.C.
        • Gilles F.H.
        Human telencephalic angiogenesis.
        Ann Neurol. 1985; 17: 539-548
        • Dambska M.
        The vascularization of the developing human brain.
        Folia Neuropathol. 1995; 33: 189-193
        • Soriano E.
        • Alvarado-Mallart R.M.
        • Dumesnil N.
        • Del Rio J.A.
        • Sotelo C.
        Cajal–Retzius cells regulate the radial glia phenotype in the adult and developing cerebellum and alter granule cell migration.
        Neuron. 1997; 18: 563-577
        • Super H.
        • Del Rio J.A.
        • Martinez A.
        • Perez-Sust P.
        • Soariano E.
        Disruption of neuronal migration and radial glia in the developing cerebral cortex following ablation of Cajal-Retzius cells.
        Cereb Cortex. 2000; 10: 602-613
        • Sotelo C.
        • Soriano E.
        Finding a role for Cajal–Retzius cells in cerebral cortex development.
        in: Galaburda A.M. Christen Y. Normal and abnormal development in the cortex. Springer-Verlag, Berlin, Heidelberg, New York1997: 67-79
        • Super H.
        • Perez-Sust P.
        • Soriano E.
        Survival of Cajal–Retzius cells after cortical lesions in newborn mice: a possible role of Cajal–Retzius cells in brain repair.
        Brain Res Dev Brain Res. 1997; 98: 9-14
        • Marin-Padilla M.
        Developmental neuropathology and impact of perinatal brain damage. III: gray matter lesions of the neocortex.
        J Neuropath Exp Neurol. 1999; 58: 407-429
        • Prayson R.A.
        • Estes M.L.
        Cortical dysplasia: a histopathologic study of 52 cases of partial lobectomy in patients with epilepsy.
        Hum Pathol. 1995; 26: 493-500
        • Kaufmann W.E.
        • Galaburda A.M.
        Cerebrocortical microdysgenesis in neurologically normal subjects: a histolopathologic study.
        Neurology. 1989; 39: 238-244