Abstract
Rett syndrome (RS) is a particular neurodevelopmental disorder in which symptoms develop
in early infancy and manifests particular symptoms at certain ages. Two girls aged
4.5 and 2.5-years-old were admitted with complaints of seizures, regression of language,
psychomotor development, and autistic behavior. They had fulfilled the criteria of
classic RS. Lamotrigine was used in the treatment of the convulsions. After lamotrigine
therapy, the convulsions were successfully controlled and the stereotyped hand movements
and autistic behaviors markedly decreased. We would like to stress that, aside from
convulsion, abnormal signs of the syndrome such as stereotyped hand movements and
autistic behaviors might also be improved with lamotrigine, but detailed and controlled
studies should be performed to identify whether lamotrigine has any positive effects
in RS.
Keywords
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References
- Über ein eigenartiges hirnatrophisches syndrom bei hyperammoniamie in Kindesalter.Wien Med Wochens. 1966; 116 (cited in ref. 2): 378-723
- A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases.Ann Neurol. 1983; 14: 471-479
- The nervous system.in: Behrman R.E. Kliegman R.M. Jenson H.B. Textbook of pediatrics. 16th ed. WB Saunders, Philadelphia2000: 1793-1866
- Possible lesions of the Rett syndrome: opinions of contributors.Brain Dev. 1992; 14: S149-S150
- Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.Nat Genet. 1999; 23: 185-188
- Lamotrigine in Rett syndrome.Neuropediatrics. 1993; 24: 339-340
- Elevated CSF glutamate in Rett syndrome.Neuropediatrics. 1992; 23: 212-213
- Neurochemical and behavioral aspects of Lamotrigine.Epilepsy. 1991; 32: 4-8
- The Rett syndrome: magnetic resonance imaging and clinical findings in four girls.Brain Dev. 1989; 11: 175-178
- Cerebral magnetic resonance spectroscopy in Rett syndrome failure to detect mitochondrial disorder.Brain Dev. 1992; 15: 107-112
- Cerebellar and cerebral abnormalities in Rett syndrome: a quantitative MR analysis.AJR. 1992; 159: 177-183
- Rett syndrome: controlled study of an oral opiate antagonist, naltrexone.Ann Neurol. 1994; 35: 464-470
- A double blind trial of bromocriptine in the Rett syndrome.Brain Dev. 1990; 12: 148-150
- Bromocriptine in the Rett syndrome.Brain Dev. 1990; 12: 221-225
- Biochemical and clinical effects of tyrosine and tryptophan in Rett syndrome.Brain Dev. 1990; 12: 143-147
- Magnesium for hyperventilation in Rett's syndrome.Lancet. 1992; 340: 621-622
- Rett syndrome - an early catecholamine and indolamine deficient disorder?.Brain Dev. 1985; 7: 334-341
- Pathophysiology of Rett syndrome from the standpoint of early catecholamine disturbance.Eur Child Adolesc Psychiatry. 1997; 6: 56-60
- Rett syndrome: Stimulation of endogenous biogenic amines.Neuropediatrics. 1992; 23: 131-137
- Neurochemistry of the Rett syndrome.Brain Dev. 1992; 14: S57-S62
Article info
Publication history
Accepted:
January 23,
2001
Received in revised form:
January 22,
2001
Received:
October 8,
2000
Identification
Copyright
© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
