Abstract
The clinical course of Japanese patients with childhood and adolescent adrenoleukodystrophy
(ALD) who were treated with Lorenzo's oil after the progression of early symptoms
was investigated by Kaplan–Meier analyses. Many of the early symptoms, including visual,
personality, hearing, mental and speech disturbances, had already appeared when the
oil therapy was started. These early symptoms appeared significantly faster than bed-ridden
state or dysphagia (P<0.01). Gait disturbance appeared faster than bed-ridden state and dysphagia (P<0.05), and tended to appear later than the early symptoms. These results would reflect
the early natural course of childhood and adolescent ALD before treatment, and provide
a basis for the evaluation of therapeutic trials for ALD.
Keywords
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Article info
Publication history
Accepted:
November 14,
2000
Received in revised form:
November 1,
2000
Received:
July 21,
2000
Identification
Copyright
© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
