Abstract
Although once thought to be rare, malformations of cortical development are being
increasingly recognized as the underlying cause of developmental delay in children
and of epilepsy in children and young adults. Advances in neuroimaging and developmental
neurobiology have created the tools by which these important malformations have been
investigated. Through a symbiotic type of relationship, these investigations, and
the search for a better understanding of these malformations, have led to advances
in neuroimaging techniques and better understanding of both normal and abnormal brain
development. In this review, the most common malformations or cortical development
associated with epilepsy are discussed in regard to their clinical manifestations,
classification, imaging appearance and basic neurobiology.
Keywords
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Article info
Publication history
Accepted:
November 15,
2000
Received in revised form:
November 9,
2000
Received:
August 28,
2000
Identification
Copyright
© 2001 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
