Abstract
We report on an 18-month-old girl with a seizure frequency of five/day, receiving
an antiepileptic polytherapy consisting of primidone, clonazepam and phenytoin. Following
discontinuation of clonazepam and primidone, the patient has been seizure-free under
monotherapy for 2 years and shows marked developmental progress. Possible mechanisms
of this paradoxical effect of antiepileptic drugs and the implications for antiepileptic
therapy are discussed.
Keywords
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References
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Article info
Publication history
Accepted:
March 27,
2000
Received in revised form:
March 27,
2000
Received:
July 8,
1999
Identification
Copyright
© 2000 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
