A case of neonatal human parechovirus encephalitis with a favourable outcome

      Abstract

      Human parechoviruses (HPeVs) are a new family of neurotropic viruses that cause central nervous system (CNS) infections similar to enterovirus (EVs) meningoencephalitis in the neonatal period, resulting in white matter lesions that can be visualized with cranial ultrasonography and magnetic resonance imaging, and correlated to a large spectrum of neurological outcomes. HPeV should be suspected in neonates with signs and symptoms of sepsis-like illness or CNS disease. We report a case of neonatal HPeV encephalitis, diagnosed on the basis of clinical and radiological findings and HPeV RT-PCR, with a good neurological outcome.

      Abbreviations:

      HPeV (human parechovirus), EV (human enterovirus), CNS (central nervous system), MRI (magnetic resonance imaging), RT-PCR (reverse transcription polymerase chain reaction), CSF (cerebral spinal fluid), DWI (diffusion-weighted imaging), ICU (intensive care unit)

      Keywords

      To read this article in full you will need to make a payment
      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Boivin G.
        • Abed Y.
        • Boucher F.D.
        Human parechovirus 3 and neonatal infections.
        Emerg Infect Dis. 2005; 11: 103-105
        • Calvert J.
        • Chieochansin T.
        • Benshop K.S.
        • McWilliam Leitch E.C.
        • Drexler J.F.
        • Grywna K.
        • et al.
        Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates.
        J Gen Virol. 2010; 91: 1229-1238
        • Legay V.
        • Chomel J.J.
        • Fernandez E.
        • Lina B.
        • Aymard M.
        • Khalfan S.
        Encephalomyelitis due to human parechovirus type 1.
        J Clin Virol. 2002; 25: 193-195
        • Benshop K.S.M.
        • Schinkel J.
        • Minnaar R.P.
        • Pajkrt D.
        • Spanjerberg L.
        • Kraakman H.C.
        • et al.
        Human parechovirus infections in Dutch children and the association between serotype and disease severity.
        Clin Infect Dis. 2006; 42: 204-210
        • Verboon-Maciolek M.A.
        • Groenendaal F.
        • Hahn C.D.
        • Hellmann J.
        • van Loon A.M.
        • Boivin G.
        • et al.
        Human parechovirus causes encephalitis with white matter injury in neonates.
        Ann Neurol. 2008; 64: 266-273
        • Verboon-Maciolek M.A.
        • Gronendaal F.
        • Cowan F.
        • Govaert P.
        • van Loon A.M.
        • de Vries L.S.
        White matter damage in neonatal enterovirus meningoencephalitis.
        Neurology. 2006; 66: 1267-1269
        • Gupta S.
        • Fernandez D.
        • Siddiqui A.
        • Tong W.C.Y.
        • Pohl K.
        • Jungbluth H.
        Extensive white matter abnormalities associated with neonatal parechovirus (HPeV) infection.
        Eur J Paediatr Neurol. 2010; 14: 531-534
        • Nix A.W.
        • Maher K.
        • Johansson S.E.
        • Niklasson B.
        • Lindberg A.M.
        • Pallansch M.A.
        • et al.
        Detection of all known parechovirus by real-time PCR.
        J Clin Microbiol. 2008; 46: 2519-2524
        • Harvala H.
        • Robertson I.
        McWilliam Leitch EC, Benschop K, Wolthers KC, Templeton K, Simmonds P. Epidemiology and clinical associations of human parechovirus respiratory infections.
        J Clin Microbiol. 2008; 46: 3446-3453
        • Pineiro L.
        • Vicente D.
        • Montes M.
        • Hernandez-Dorronsoro U.
        • Cilla G.
        Human parechoviruses in infants with systemic infection.
        J Med Virol. 2010; 82: 1790-1796