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Abstract
In this study, the right cerebral cortices of mice on postnatal day 0 (P0) were cryocoagulated
with dry ice. Subsequent development of the corticospinal tract (CST) was studied
morphologically and quantitatively, and was compared with that in age-matched controls.
When the pyramidal tract was traced anterogradely by injecting HRP into the sensorimotor
area of the left cerebral cortex of adult operated mice, the right CST originating
from the healthy left hemisphere showed remarkable hypertrophy. The number of axons
in the CST at the C4–C6 level became maximum on P14 in the control mice and rapidly
decreased thereafter. In the operated mice, the axonal number in the right CST also
was maximal on P14 and then rapidly decreased. However, the decrease in axonal number
after P21 was less in the operated mice than in the controls. Moreover, the number
of axons showed a slight increase after P56. These results indicate that the physiological
elimination of the parent axons and their collaterals is much lower in the operated
mice than in the controls, and that the increase in axon collaterals from parent axons
in the hypertrophic right CST persists a long time in the operated mice.
Keywords
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Article info
Publication history
Accepted:
December 7,
1995
Received:
August 31,
1995
Identification
Copyright
© 1996 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
