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Full length article| Volume 18, ISSUE 1, P29-34, January 01, 1996

Development of corticospinal tract fibers and their plasticity I: Quantitative analysis of the developing corticospinal tract in mice

DOI:https://doi.org/10.1016/0387-7604(95)00102-6
Development of corticospinal tract fibers and their plasticity I: Quantitative analysis of the developing corticospinal tract in mice
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      Abstract

      This study was undertaken to elucidate ultrastructurally and quantitatively the development of the corticospinal tract (CST) axons of mouse at the intumescence level of the cervical cord. An anterograde HRP study showed that the CST was located at the ventral one-third of the dorsal funiculus, and a few HRP-positive fibers were noted at the medialmost part of the ipsilateral anterior funiculus. Ultrastructurally, the CST was composed of unmyelinated axons, growth cones and a few degenerating axons until postnatal day 10 (P10), then the axons in CST gradually increased in size. The number of axons constituting the right CST was calculated at different days of age. The total numbers of axons at P0, P4, P14, P21 and P56 were 2.3 × 104, 6.2 × 104, 10.4 × 104, 7.1 × 104 and 3.5 × 104, respectively. These results indicate that the number of CST axons at the cervical intumescence of mouse becomes maximum at P14, and then decreases rapidly to reach the adult level of 3.5 × 104 (at P56), about 68% of them thus being lost.

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      Reference

        • Brown L.T.
        Projections and termination of the corticospinal tract in rodents.
        Exp Brain Res. 1971; 13: 432-450
        • Hicks S.P.
        • D'Amato C.J.
        Motor-sensory cortex-corticospinal system and developing locomotion and placing in rats.
        Am J Anat. 1975; 143: 1-42
        • Wise S.P.
        • Murray E.A.
        • Coulter J.D.
        Somatotopic organization of corticospinal and corticotrigeminal neurons in the rat.
        Neuroscience. 1979; 4: 65-78
        • Kalil K.
        • Reh T.
        Redirection of pyramidal tract axons in neonatal hamster: some mechanisms of guidance during development.
        Soc Neurosci. 1979; 5: 629
        • Jones E.G.
        • Schreyer D.J.
        • Wise S.P.
        Growth and maturation of the corticospinal tract.
        Prog Brain Res. 1982; 57: 361-379
        • Stanfield B.B.
        • O'Leary D.D.M.
        • Fricks C.
        Selective collateral elimination in early postnatal development restricts cortical distribution of rat pyramidal tract neurons.
        Nature. 1982; 298: 371-373
        • Terashima T.
        • Inoue K.
        • Mikoshiba K.
        • Tsukada Y.
        Distribution and morphology of corticospinal tract neurons in Reeler mouse cortex by the retrograde HRP method.
        J Comp Neurol. 1983; 218: 314-326
        • Gribnau A.A.M.
        • de Kort E.J.M.
        • Dederen P.J.W.C.
        • Nieuwenhuys R.
        On the development of the pyramidal tract in the rat. II. An anterograde tracer study of the outgrowth of the corticospinal fibers.
        Anat Embryol. 1986; 175: 101-110
        • Neafsey E.J.
        • Bold E.L.
        • Haas G.
        • et al.
        The organization of the rat motor cortex: a microstimulation mapping study.
        Brain Rev. 1986; 11: 77-96
        • Miller M.W.
        The origin of corticospinal projection neurons in rat.
        Exp Brain Res. 1987; 67: 339-351
        • Joosten E.A.J.
        • van Eden C.G.
        An anterograde tracer study on the development of corticospinal projections from the medial prefrontal cortex in the rat.
        Dev Brain Res. 1989; 45: 313-319
        • Wise S.P.
        • Donoghue J.P.
        Motor cortex of rodents.
        in: 5th edn. Cerebral cortex, vol. 5. Sensory-motor areas and aspects of cortical connectivity. Plenum Press, New York1986: 243-265
        • Ono K.
        • Shimada M.
        • Yamano T.
        Reorganization of the corticospinal tract following neonatal unilateral cortical ablation in rats.
        Brain Dev (Tokyo). 1990; 12: 226-236
        • Ono K.
        • Yamano T.
        • Shimada M.
        Formation of an ipsilateral corticospinal tract after ablation of cerebral cortex in neonatal rat.
        Brain Dev (Tokyo). 1991; 13: 348-351
        • de Kort E.J.M.
        • Gribnau A.A.M.
        • van Aanholt H.T.H.
        • Nieuwenhuys R.
        On the development of the pyramidal tract in the rat. I. The morphology of the growth zone.
        Anat Embryol. 1985; 172: 195-204
        • Schreyer D.J.
        • Jones E.G.
        Growth and target finding by axons of the corticospinal tract in prenatal and postnatal rats.
        Neuroscience. 1982; 7: 1835-1837
        • Gorgels T.G.M.F.
        A quantitative analysis of axon outgrowth, axon loss, and myelination in the rat pyramidal tract.
        Dev Brain Res. 1990; 54: 51-61
        • Joosten E.A.J.
        • Bar P.R.
        • Gispen W.H.
        Corticospinal axons and mechanism of target innervation in rat lumbar spinal cord.
        Dev Brain Res. 1994; 79: 122-127
        • Curfs M.H.J.M.
        • Gribnau A.A.M.
        • Dederen P.J.W.C.
        Selective elimination of transient corticospinal projections in the rat cervical spinal cord gray matter.
        Dev Brain Res. 1994; 78: 182-190
        • Gorgels T.G.M.F.
        • De Kort E.J.M.
        • Van Aanholt H.T.H.
        • Nieuwenhuys R.
        A quantitative analysis of the development of the pyramidal tract in the cervical spinal cord in the rat.
        Anat Embryol. 1989; 179: 377-385
        • Matthews M.A.
        • Duncan D.
        A quantitative study of morphological changes accompanying the initiation and progress of myelin production in the dorsal funiculus of the rat spinal cord.
        J Comp Neurol. 1971; 142: 1-22

      Article Info

      Publication History

      Accepted: July 13, 1995
      Received: May 19, 1995

      Identification

      DOI: https://doi.org/10.1016/0387-7604(95)00102-6

      Copyright

      © 1996 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.

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