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Abstract
A previously healthy 8-month-old girl developed exanthem subitum and acute encephalopathy
with status epilepticus, quadriplegia and bilateral abducens nerve palsies. Human
herpesvirus-6 DNA was found in the cerebrospinal fluid by the polymerase chain reaction
at the acute stage. Cranial computed tomography showed low density areas in the thalami
and in the cerebellar and abducens nuclei. The distribution of the lesions was consistent
with acute necrotizing encephalopathy. As for the thalamic lesions, a T2 weighted
magnetic resonance image on the 24th day of the illness demonstrated low signal intensity
surrounded by high intensity;99mTc-ECD SPECT showed hypoperfusion, which suggested irreversible tissue damage. The
patient is now 1 year 6 months old and has spastic quadriparesis with mental retardation
and abducens nerve palsies.
Keywords
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Article info
Publication history
Accepted:
June 29,
1995
Received:
April 4,
1995
Identification
Copyright
© 1995 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
