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Abstract
The effects of rapid rectal diazepam introduction (DZP test) were investigated in
43 patients (age range 5 months-14 years) with electrical status epilepticus (ESE)
undergoing EEG monitoring. A remission of the paroxysmal activity was obtained in
58% of cases, a negative response in 42%, particularly in hypsarrhythmic patterns.
DZP test responders were aged over 12 months with organized paroxysmal EEG patterns,
in particular with ESE during sleep (ESES). The patients who responded to the DZP
test underwent short cycles (3–4 weeks) of relatively high dosage DZP (0.5–0.75 mg/kg).
The response to treatment was positive in 64%, particularly in ESES conditions. 56%
of responders to the DZP test but not to DZP therapy (five out of nine patients) presented
a significant mental retardation; maturational factors were also likely to be present.
Keywords
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Reference
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Article info
Publication history
Accepted:
July 4,
1995
Received:
February 3,
1995
Identification
Copyright
© 1995 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
