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Research Article| Volume 17, ISSUE 5, P312-316, September 1995

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Cerebral hemodynamics on near-infrared spectroscopy in hypoxia and ischemia in young animal studies

  • Sachio Takashima
    Correspondence
    Corresponding author. Fax: (81) (423) 46-1743.
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Satoru Hirano
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Satoshi Kamei
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Motohiro Hasegawa
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Hirofumi Kimoto
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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DOI:https://doi.org/10.1016/0387-7604(95)00072-J
Cerebral hemodynamics on near-infrared spectroscopy in hypoxia and ischemia in young animal studies
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      Abstract

      Using near-infrared spectroscopy the changes of intracranial oxyhemoglobin, deoxyhemoglobin, total hemoglobin and cytochrome aa3, which show the progression of intracranial oxygenation, hemodynamics and cell metabolism, were recorded during prolonged partial hypoxia induced by carbon dioxide (CO2) and nitrogen (N2), ischemia induced by hyperventilation, and hypoxia during hypoglycemia in neonatal and young rabbits. The reduction of cytochrome aa3 during the terminal stage of CO2-induced prolonged hypoxia, hyperventilation and hypoxia in hypoglycemia suggests that the redox state of cytochrome aa3 will be changed by several combined factors such as oxygen delivery, ATP demand and substrate (glucose) delivery.

      Keywords

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      Article info

      Publication history

      Accepted: June 20, 1995
      Received: March 14, 1995

      Footnotes

      This paper was presented at the Symposium ‘Cerebral hemodynamics in the newborn; Studies with near-infrared spectroscopy’ at the First Conjoint Meeting of Child Neurology Society and International Child Neurology Association (23rd National Meeting of CNS and 7th Congress of ICNA), San Francisco, 2–7 October, 1994.

      Identification

      DOI: https://doi.org/10.1016/0387-7604(95)00072-J

      Copyright

      © 1995 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.

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