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Cerebral hemodynamics on near-infrared spectroscopy in hypoxia and ischemia in young animal studies

  • Sachio Takashima
    Correspondence
    Corresponding author. Fax: (81) (423) 46-1743.
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Satoru Hirano
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Satoshi Kamei
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Motohiro Hasegawa
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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  • Hirofumi Kimoto
    Affiliations
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan
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      Abstract

      Using near-infrared spectroscopy the changes of intracranial oxyhemoglobin, deoxyhemoglobin, total hemoglobin and cytochrome aa3, which show the progression of intracranial oxygenation, hemodynamics and cell metabolism, were recorded during prolonged partial hypoxia induced by carbon dioxide (CO2) and nitrogen (N2), ischemia induced by hyperventilation, and hypoxia during hypoglycemia in neonatal and young rabbits. The reduction of cytochrome aa3 during the terminal stage of CO2-induced prolonged hypoxia, hyperventilation and hypoxia in hypoglycemia suggests that the redox state of cytochrome aa3 will be changed by several combined factors such as oxygen delivery, ATP demand and substrate (glucose) delivery.

      Keywords

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      Reference

        • Volpe J.J.
        Neurology of the newborn.
        in: 2nd edn. Saunders, Philadelphia1995: 279-307
        • Myers R.E.
        Four patterns of perinatal brain damage and their conditions of occurrence in primates.
        Adv Neurol. 1975; 10: 223-234
        • Jobsis F.F.
        Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.
        Science. 1977; 198: 1264-1267
        • Wray S.
        • Cope M.
        • Delpy D.T.
        • Wyatt J.S.
        • Reynolds E.O.R.
        Characterization of the near-infrared absorption spectra of cytochrome aa3 and hemoglobin for the noninvasive monitoring of cerebral oxygenation.
        Biochim Biophys Acta. 1988; 933: 184-192
        • Tamura M.
        • Hazeki O.
        • Nioka S.
        • Chance B.
        • Smith D.S.
        The simultaneous measurements of tissue oxygen concentration and energy state by near-infrared and nuclear magnetic resonance spectroscopy.
        Adv Exp Med Biol. 1988; 222: 359-363
        • Wyatt J.S.
        • Cope M.
        • Delpy D.T.
        • Wray S.
        • Reynolds E.O.R.
        Quantitation of cerebral oxygenation and hemodynamics in sick newborn infants by near infrared spectroscopy.
        Lancet. 1986; ii: 1053-1056
        • Ferrari M.
        • Giannini I.
        • Sideri G.
        • Zanette F.
        Continuous noninvasive monitoring of human brain by near infrared spectroscopy.
        Adv Exp Med Biol. 1985; 191: 873-882
        • Yoshioka H.
        • Chance B.
        • Papadopoulos M.D.
        • Sawada T.
        Observation of cerebral hemodynamics and oxygenation in sick neonates by near-infrared spectroscopy.
        Brain Dysfunct. 1991; 4: 28-31
        • Hasegawa M.
        • Houdou S.
        • Takashima S.
        • Tatsuno M.
        • Okuyama K.
        • Suzuki S.
        Monitoring of immature rabbit brain during hypoxia with near infrared spectroscopy.
        Pediatr Neurol. 1992; 8: 47-50
        • Takashima S.
        • Tanaka K.
        Development of cerebrovascular architecture; Its relationship to periventricular leukomalacia.
        Arch Neurol. 1978; 35: 11-16
        • De Reuck J.
        • Chattha A.S.
        • Richardson K.P.
        Pathogenesis and evolution of periventricular leukomalacia in infancy.
        Arch Neurol. 1972; 27: 229-236
        • Takashima S.
        • Becker L.E.
        • Tanaka J.
        Developmental changes of glial fibrillary acidic protein and myelin basic protein in perinatal leukomalacia; relationship to a predisposing factor.
        Brain Dev (Tokyo). 1984; 6: 444-450
        • Iida K.
        • Takashima S.
        • Takeuchi Y.
        Etiologies and distribution of neonatal leukomalacia.
        Pediatr Neurol. 1992; 8: 203-209
        • Iida K.
        • Takashima S.
        Immunohistochemical study on glial cells in brains with periventricular leukomalacia.
        Neuropathology (Kyoto). 1993; 13: 285-290
        • Hansen N.B.
        • Brubakk A.
        • Bratlid D.
        • Stonestreet B.S.
        The effects of variations in PaCO2 on brain blood flow and cardiac output, and blood pressure of normal young men.
        J Clin Invest. 1984; 25: 107-119
        • Reuter J.H.
        • Disney T.A.
        Regional cerebral blood flow and cerebral metabolic rate of oxygen during hyperventilation in the newborn dog.
        Pediatr Res. 1986; 20: 1102-1106
        • Sugioka K.
        • Davis D.A.
        Hyperventilation with oxygen: a possible cause of cerebral hypoxia.
        Anesthesiology. 1960; 21: 135-143
        • Wilson D.F.
        • Pastuszko A.
        • DiGiacomo J.E.
        • Pawlowski M.
        • Schneiderman R.
        • Delivoria-Papadopoulos M.
        Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets.
        J Appl Physiol. 1991; 70: 2691-2696
        • Calvert S.A.
        • Hoskins E.M.
        • Fong K.W.
        Etiological factors associated with the development of periventricular leukomalacia.
        Acta Paediatr Scand. 1987; 76: 254-259
        • Hashimoto K.
        • Takeuchi Y.
        • Takashima S.
        Hypocarbia as a pathogenetic factor in pontosubicular necrosis.
        Brain Dev (Tokyo). 1991; 13: 155-157
        • Greisen G.
        • Munck H.
        • Lou H.
        Severe hypocarbia in preterm infants and neurodevelopmental deficit.
        Acta Pediatr Scand. 1987; 76: 401-404
        • Kamei A.
        • Ozaki T.
        • Takashima S.
        Monitoring of the intracranial hemodynamics and oxygenation during and after hyperventilation in newborn rabbits with near-infrared spectroscopy.
        Pediatr Res. 1994; 35: 334-338
        • Kogure K.
        • Busto R.
        • Matsumoto A.
        • Scheinberg P.
        • Reinmuth M.
        Effect of hyperventilation on dynamics of cerebral energy metabolism.
        Am J Physiol. 1975; 228: 1862-1867
        • Reivich M.
        • Cohen P.J.
        • Greenbaum I.
        Alterations in the electroencephalogram of awake man produced by hyperventilation: effects of 100% O2 oxygen at 3 atmosphere (absolute) pressure.
        Neurology. 1966; 16: 304
        • Kennealy J.A.
        • McLennan J.E.
        • Loudon R.G.
        • McLaurin R.I.
        Hyperventilation induced cerebral hypoxia.
        Am Rev Respir Dis. 1980; 122: 402-412
        • Plum F.
        • Posner J.B.
        • Smith W.W.
        Effect of hyperbaric-hyperoxic hyperventilation on blood, brain, and CSF lactate.
        Am J Physiol. 1968; 215: 1240-1244
        • Tsuji M.
        • Naruse H.
        • Volpe J.
        • Holtzman D.
        Reduction of cytochrome aa3 measured by near-infrared spectroscopy predicts cerebral energy loss in hypoxic piglets.
        Pediatr Res. 1995; 37: 253-259
        • Casaer P.
        • v Siebenthal K.
        • van der Vlugt A.
        • Lagae L.
        • Devlieger H.
        Cytochrome aa3 and intracranial pressure in newborn infants; A near infrared spectroscopy study.
        Neuropediatrics. 1992; 23: 111