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Abstract
We report four Japanese cases of multiple sclerosis (MS) starting during childhood.
In three of them, onset occurred in the prepubertal period. Case 1 showed a rare clinical
condition: the patient presented with Devic disease, and 2 years later she was complicated
by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The other three
cases had symptoms of gait disturbance, cerebellar signs, weakness of the extremities
and impaired visual acuity. Headache was seen in Case 2 and medial longitudinal fasciculus
(MLF) syndrome in Case 4. In Cases 2, 3 and 4, diagnoses were conclusively made by
T2-weighted magnetic resonance imaging (MRI). MRI, brain stem auditory, visual and somatosensory
evoked potentials are extremely useful for evaluating the clinical conditions of children
with MS.
Keywords
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Article info
Publication history
Accepted:
October 2,
1993
Received:
March 12,
1993
Identification
Copyright
© 1994 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
