Research Article| Volume 16, ISSUE 1, P52-56, January 1994

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Childhood multiple sclerosis: MR images and clinical variations in four Japanese cases

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      We report four Japanese cases of multiple sclerosis (MS) starting during childhood. In three of them, onset occurred in the prepubertal period. Case 1 showed a rare clinical condition: the patient presented with Devic disease, and 2 years later she was complicated by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The other three cases had symptoms of gait disturbance, cerebellar signs, weakness of the extremities and impaired visual acuity. Headache was seen in Case 2 and medial longitudinal fasciculus (MLF) syndrome in Case 4. In Cases 2, 3 and 4, diagnoses were conclusively made by T2-weighted magnetic resonance imaging (MRI). MRI, brain stem auditory, visual and somatosensory evoked potentials are extremely useful for evaluating the clinical conditions of children with MS.


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        • Duquette P
        • Murray T.J.
        • Pleines J
        • et al.
        Multiple sclerosis in childhood: clinical profile in 125 patients.
        J Pediatr. 1987; 111: 359-363
        • Lowis G.W.
        The social epidemiology of multiple sclerosis.
        Sci Total Environ. 1990; 90: 163-190
        • Hanefeld F
        • Bauer H.J.
        • Christen H.J.
        • Kruse B
        • Bruhn H
        • Frahm J
        Multiple sclerosis in childhood: report of 15 cases.
        Brain Dev (Tokyo). 1991; 13: 410-416
        • Scaioli V
        • Rumi V
        • Cimino C
        • Angelini L
        Childhood multiple sclerosis (MS): multimodal evoked potentials (EP) and magnetic resonance imaging (MRI) comparative study.
        Neuropediatrics. 1991; 22: 15-23
        • Maeda Y
        • Kitamoto I
        • Kurokawa T
        • Ueda K
        • Hasuo K
        • Fujioka K
        Infantile multiple sclerosis with extensive white matter lesions.
        Pediatr Neurol. 1989; 5: 317-319
        • Haas G
        • Schroth G
        • Krageloh-Mann I
        • Buchwald-Saal G
        Magnetic resonance imaging of the brain of children with multiple sclerosis.
        Dev Med Child Neurol. 1987; 29: 586-591
        • Bauer H.J.
        • Hanefeld F
        • Christen H.J.
        Multiple sclerosis in early childhood.
        Lancet. 1990; 336: 1190
        • Watanabe Y
        • Ishikawa Y
        • Wakai S
        • Tachi N
        • Chiba S
        A case of multiple sclerosis associated with chronic inflammatory demyelinating polyradiculoneuropathy.
        No To Hattatsu. 1993; 25 (in Japanese): 70-75
        • Zee P.C.
        • Cohen B.A.
        • Walczak T
        • Jubelt B
        Peripheral nervous system involvement in multiple sclerosis.
        Neurology. 1991; 41: 457-460
        • Lassmann H
        • Bukda H
        • Schnaberth G
        Inflammatory demyelinating polyradiculitis in a patient with multiple sclerosis.
        Arch Neurol. 1981; 38: 99-102
        • Ro Y.I.
        • Alexander C.B.
        • Oh S.J.
        Multiple sclerosis and hypertrophic demyelinating peripheral neuropathy.
        Muscle Nerve. 1983; 6: 312-316
        • Fukuyama Y
        • Hirano S
        • Shibazaki H
        • et al.
        Clinical profile of childhood multiple sclerosis in the nationwide survey.
        (in Japanese)in: Nishitani H The 1990 Annual reprot of the research committee on immuno-neurological diseases. 1991: 100-103 (sponsored by the Ministry of Health and Welfare, Japan. Kyoto)
        • Mendell J.R.
        • Kolkin S
        • Kissel J.T.
        • Weiss K.L.
        • Chakeres D.W.
        • Rammohan K.W.
        Evidence for central nervous system demyelinating polyradiculoneuropathy.
        Neurology. 1987; 37: 1291-1294
        • Adams R.D.
        • Victor M
        Multiple sclerosis and allied demyelinative diseases.
        in: Adams R.D. Principles of neurology. McGraw-Hill, New York1993: 792-794
        • Bye A.M.E.
        • Kendall B
        • Wilson J
        Multiple sclerosis in childhood: a new look.
        Dev Med Child Neurol. 1985; 27: 215-222