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The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The role of a TDM service in establishing proper pediatric anti-epileptic drug (AED) use is described. A number of studies are reviewed which identified proper pediatric dosage regimens for phenobarbital, carbamazepine, valproic acid, phenytoin and clonazepam. Finally, the potential role of TDM in the use of new AEDs is mentioned. These studies are given as examples of how professionals knowledgeable in clinical epilepsy management, clinical pharmacology and pharmacokinetics, can use TDM to design individualized dosage regimens, as well as assess compliance, toxicity and drug interactions.
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Accepted: October 19, 1993
Received: August 31, 1993
This paper was presented as an invited lecture at the 35th annual meeting of the Japanese Society of Child Neurology, Kyoto, 17–19 June 1993.
© 1994 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.