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Research Article| Volume 16, ISSUE 3, P253-256, May 1994

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Expanding spectrum of cocaine induced central nervous system malformations

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      Abstract

      Two patients born to mothers who abused cocaine during pregnancy were found to have various brain malformations, some of which were not previously reported. Children who were exposed to cocaine or polysubstances prenatally and who present with a neurologic deficit require neuroimaging studies to detect abnormalities.

      Keywords

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      Reference

        • Volpe JJ
        Effect of cocaine use on the fetus.
        N Engl J Med. 1992; 327: 399-407
        • Bingol N
        • Fuchs M
        • Diaz V
        • et al.
        Teratogenicity of cocaine in humans.
        J Pediatr. 1987; 110: 93-96
        • Chasnoff IJ
        • Bussey ME
        • Savich R
        • et al.
        Perinatal cerebral infarction in maternal cocaine use.
        J Pediatr. 1986; 108: 456-459
        • Dominiguez R
        • Aguirre Vila-Coro A
        • Slopis JM
        Brain and ocular abnormalities in infants with in utero exposure to cocaine and other street drugs.
        Am J Dis Child. 1992; 145: 688-695
        • Heier LA
        • Carpanzano CR
        • Mast J
        • et al.
        Maternal cocaine abuse: the spectrum of radiologic abnormalities in the neonatal CNS.
        AJNR. 1991; 12: 951-956
        • Lavi E
        • Montone KT
        • Rorke LB
        • et al.
        Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.
        Neurology. 1991; 41: 1467-1468
        • Seatriz JV
        • Hammer Jr, RP
        Effects of opiates on neuronal development in the rat cerebral cortex.
        Brain Res Bull. 1993; 30: 523-527
        • Gressens P
        • Gofflot F
        • Van Maele-Fabry G
        • et al.
        Early neurogenesis and teratogenesis in whole mouse embryo cultures. Histochemical, immunocytological and ultrastructural study of the premigratory neuronal-glial units in normal mouse embryo and in mouse embryos influenced by cocaine and retinoic acid.
        J Neuropathol Exp Neurol. 1992; 51: 206-219
        • Dixon SD
        • Bejar R
        Echoencephalographic findings in neonates associated with maternal cocaine and methamphetamine use: incidence and clinical correlates.
        J Pediatr. 1989; 115: 770-778
        • Gabriel RS
        • McComb JG
        Malformations of the central nervous system.
        in: Menkes JH Textbook of child neurology. Lea & Febiger, Philadelphia1985: 220-224
        • Lacey DJ
        Agenesis of corpus callosum.
        Am J Dis Child. 1985; 139: 953-955
        • Yakovlev PI
        • Wadsworth RC
        Schizencephalies. A study of the congenital clefts in the cerebral mantle. 1. Clefts with fused lips.
        J Neuropathol Exp Neurol. 1946; 5: 116-130
        • Barkovich AJ
        • Kjos BO
        Schizencephaly: correlation of clinical findings with MR characteristics.
        AJNR. 1992; 13: 85-94
        • Hoyme HE
        • Jones KL
        • Dixon SD
        • et al.
        Prenatal cocaine exposure and fetal vascular disruption.
        Pediatrics. 1990; 85: 743-747
      1. Friede RL Developmental neuropathology. Springer, New York1989: 28-43