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Abstract
A 14-year-old boy with acute lymphoblastic leukemia developed acute ascending myelitis
followed by encephalopathy after intrathecal administration of methotrexate 15 mg
and cytosine arabinoside 50 mg. The patient had none of the risk factors noted previously
in other patients with intrathecal therapy (IT) induced neurotoxicity. The doses administered
were within the standard scales, and toxicity developed in the second boost of IT
20 days after the first one. There may not be any parameters to predict the occurrence
of such severe and rare form of CNS neurotoxicity attributed to IT.
Keywords
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Reference
- Prophylaxis and treatment of leukemia in the central nervous system and other sanctuaries.Sem Oncol. 1985; 12: 131-148
- Neurotoxicity due to central nervous system therapy for childhood leukemia.Am J Pediatr Hematol Oncol. 1989; 11: 93-105
- Intrathecal methotrexate-induced neurotoxicities.Am J Hosp Pharm. 1981; 38: 65-68
- Methotrexate-related multifocal axonopathy.Acta Neuropathol. 1989; 79: 333-335
- Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia.Cancer. 1991; 67: 2058-2061
- Stroke-like syndrome, mineralizing microangiopathy, and neuroaxonal dystrophy following intrathecal methotrexate therapy.Neurology. 1991; 41: 1847-1848
- Encephalopathy in acute leukaemia associated with methotrexate therapy.Arch Dis Child. 1972; 47: 344-354
- Peripheral neuropathy associated with high-dose Ara-C therapy.Cancer. 1986; 58: 852-854
- Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type.Cancer. 1993; 71: 117-123
- Ascending myelitis after intensive chemotherapy and radiation therapy in children with intracranial parameningeal sarcoma.Cancer. 1992; 69: 1498-1506
- Paraplegia and quadriplegia after intrathecal chemotherapy.Arch Phys Med Rehabil. 1988; 69: 1054-1056
- Acute neurological toxicity of intrathecal cytosine arabinoside: a case report.Cancer Chemother Pharmacol. 1986; 16: 306-307
- Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia.N Engl J Med. 1973; 289: 770-773
Article info
Publication history
Accepted:
December 31,
1993
Received:
September 24,
1993
Identification
Copyright
© 1994 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
