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Abstract
Development of the midbrain in 260 newborn infants was studied by means of the ultrasonographic
method. The 260 infants were divided into four groups; 211 appropriate-for-date (AFD)
infants without intracranial abnormalities or chromosomal disorders, 41 light-for-date
(LFD) infants without intracranial abnormalities or chromosomal disorders, 5 cases
of Down syndrome and 3 cases of trisomy 18. The midbrain area (MBA) was measured in
transverse sections using a Sonos 1000 (YHP) within 24 h of birth. MBA of the 211
AFD infants was correlated with gestational age (GA), the standard curve being −0.0029(GA)2 + 0.2611(GA) − 3.335 (r = 0.87, P < 0.0001). MBA of the other three groups were compared with this standard curve. Thirty-seven
of the 41 LFD cases and all the Down syndrome infants showed MBA within 1.5 S.D. of
the standard curve. However, all the infants with trisomy 18 had smaller MBA than
−1.5 S.D. of the standard curve. The standard curve should be useful for assessing
the gestational age of newborn infants and for detecting abnormal development of the
brainstem in developmental disorders.
Keywords
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Reference
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Article info
Publication history
Accepted:
January 16,
1994
Received:
November 9,
1993
Identification
Copyright
© 1994 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.
