Advertisement
Review Article| Volume 16, ISSUE 3, P175-179, May 1994

Download started.

Ok

Brain tumors and anorexia nervosa syndrome

  • Eugenio Chipkevitch
    Correspondence
    Correspondence address: Dr. E. Chipkevitch, R. Br. Jaceguai 1154/113, Sa˜o Paulo, 04606-003, Brazil.
    Affiliations
    Division of Adolescent Medicine, Darcy Vargas Children's Hospital, Sa˜o Paulo, Brazil
    Search for articles by this author
DOI:https://doi.org/10.1016/0387-7604(94)90064-7
Brain tumors and anorexia nervosa syndrome
Next ArticleBrain tumors and anorexia nervosa syndrome Commentary to Chipkevitch's paper (pp. 175–9)
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      This review presents 21 cases, found in the literature, of a CNS lesion (a tumor in 19 of them) associated with emaciation, anorexia and several psychic symptoms that had led to the diagnosis of anorexia nervosa (AN). Anorexia and psychic disturbances preceded the neurologic signs and/or the correct diagnosis in all patients (by a mean of 2.9 years, range= 0.2–17years). Anorexia had begun before the age of 25 years in 18 patients of which two-thirds were females. Only a few cases fulfilled the DSM-III-R criteria for AN; the majority could be characterized as ‘atypical AN’. Although AN is usually conceived as a primarily psychogenic disorder, structural lesions of the hypothalamus (or other sites involved in food regulation) in animal models and in these human cases mimic many features of AN, suggesting the possibility of an as yet unidentified structural hypothalamic disorder to be implicated in the etiopathogeny of AN. The unusually high incidence of germ-cell tumors in this review (33%) suggests that they are more likely than other tumors to influence the limbic system toward an anorectic syndrome.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Brain and Development
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      Reference

        • Gumbinas M
        Tumors of the central and peripheral nervous systems.
        in: Altman A.J. Schwartz A.D. Malignant diseases of infancy, childhood and adolescence. 2nd ed. Saunders, Philadelphia1983: 347-367
        • Nicholson M
        • Keitel H
        • Williams J
        Pinealoma with associated hypernatremia and symptoms of anorexia nervosa.
        in: 3rd ed. Clin Proc Child Hosp. 13. 1957: 133-145
        • White L.E.
        • Hain R.F.
        Anorexia in association with a destructive lesion of the hypothalamus.
        Arch Pathol. 1959; 68: 275-281
        • Lewis I
        • Baxter D.W.
        • Stratford J.G.
        Atypical teratomas of the pineal.
        Can Med Assoc J. 1963; 89: 113-123
        • Malamud N
        Psychiatric disorder with intracranial tumors of limbic system.
        Arch Neurol. 1967; 17: 113-123
        • Laterre E.C.
        • Crabbé J
        • Durnez W
        • Brucher J.M.
        Cachexie, diabète insipide masquépar adipsie, hypogonadisme et altération du champ visuel causés par un processus encéphalitique chroniqueàprédominance hypothalamique.
        Rev Neurol. 1969; 121: 31-46
        • Lewin K
        • Mattingly D
        • Millis R.R.
        Anorexia nervosa associated with hypothalamic tumour.
        Br Med J. 1972; 2: 629-630
        • Seaver R.L.
        • Binder H.J.
        Anorexia nervosa and other anorectic states in man: general clinical considerations.
        Adv Psychosom Med. 1972; 7: 257-276
        • Daly J.J.
        • Nabarro J.D.N.
        • Powell T
        A case of anorexia.
        Br Med J. 1973; 2: 156-161
        • Heron G.B.
        • Johnston D.A.
        Hypothalamic tumor presenting as anorexia nervosa.
        Am J Psychiatry. 1976; 133: 580-582
        • Hollatz F
        • Ziolko H.U.
        Zur Differentialdiagnose der Anorexia Nervosa.
        Munch Med Wschr. 1976; 118: 263-266
        • Maroon J.C.
        • Albright L
        ‘Failure to thrive’ due to pontine glioma.
        Arch Neurol. 1977; 34: 295-297
        • Swann I
        Anorexia nervosa: a difficult diagnosis in boys.
        Practitioner. 1977; 218: 424-427
        • White J.H.
        • Kelly P
        • Dorman K
        Clinical picture of atypical anorexia nervosa associated with hypothalamic tumor.
        Am J Psychiatry. 1977; 134: 323-325
        • Goldney R.D.
        Craniopharyngioma simulating anorexia nervosa.
        J Nerv Ment Dis. 1978; 166: 135-138
        • Climo L.H.
        Anorexia nervosa associated with hypothalamic tumor: the search for clinical-pathological correlations.
        Psychiatr J Univ Ottawa. 1982; 7: 20-25
        • Weller R.A.
        • Weller E.B.
        Anorexia nervosa in a patient with an infiltrating tumor of the hypothalamus.
        Am J Psychiatry. 1982; 139: 824-825
        • Biebl W
        • Platz T
        • Kinzl J
        • Aichner F
        Ein Fall von mxnnlicher ‘atypisher Anorexia nervosa’: Tumor im Bereich des 3. Ventrikels.
        Nervenarzt. 1984; 55: 265-268
        • Cheyne K.L.
        • Lightner E.S.
        • Comerci G.D.
        Bromocriptine-unresponsive prolactin macroadenoma in a prepubertal female.
        J Adolesc Health Care. 1988; 9: 331-334
        • McClean P
        • Redmond A.O.B.
        Hypothalamic tumour presenting as anorexia nervosa.
        Ulster Med J. 1988; 57: 224-227
        • Trabert W
        • Reif J
        Anorexia nervosa, epileptische Anfälle und schizophreniforme Psychose bei einem temporo-basalen Angiom.
        Nervenarzt. 1990; 61: 57-60
        • Chipkevitch E
        • Fernandes A.C.L.
        Hypothalamic tumor associated with atypical forms of anorexia nervosa and diencephalic syndrome.
        Arq Neuropsiquiatr. 1993; 51: 270-274
        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders.
        3rd ed. American Psychiatric Association, Washington DC1987 (revised)
        • Carmel P.W.
        Surgical syndromes of the hypothalamus.
        Clin Neurosurg. 1980; 27: 133-159
        • Plum F
        • Van Uitert R
        Nonendocrine diseases and disorders of the hypothalamus.
        in: Reichlin S The hypothalamus. Raven Press, New York1978: 415-473
        • Bruch H
        Eating disorders: obesity, anorexia nervosa and the person within.
        Basic Books, New York1973
        • Schwabe A.D.
        • Lippe B.M.
        • Chang J
        • Pops M.A.
        • Yager J
        Anorexia nervosa.
        Ann Intern Med. 1981; 94: 371-381
        • Mecklenburg R.S.
        • Loriaux D.L.
        • Thompson R.H.
        • Andersen A.E.
        • Lipsett M.B.
        Hypothalamic dysfunction in patients with anorexia nervosa.
        Medicine. 1974; 53: 147-159
        • Katz J.L.
        • Weiner H
        A functional, anterior hypothalamic defect in primary anorexia nervosa?.
        Psychom Med. 1975; 37: 103-105
        • Anand B.K.
        • Brobeck J.R.
        Hypothalamic control of food intake in rats and cats.
        Yale J Biol Med. 1951; 24: 123-140
        • Teitelbaum P
        • Epstein A.N.
        The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions.
        Psychol Rev. 1962; 69: 74-90
        • Baillie P
        • Morrison S.D.
        The nature of the suppression of food intake by lateral hypothalamic lesions in rats.
        J Physiol. 1963; 165: 227-245
        • Powley T.L.
        • Keesey R.E.
        Relationship of body weight to the lateral hypothalamic feeding syndrome.
        J Comp Physiol Psychol. 1970; 70: 25-36
        • Bauer H.G.
        Endocrine and other clinical manifestations of hypothalamic disease.
        J Clin Endocrinol Metab. 1954; 14: 13-31
        • Herzog D.B.
        • Copeland P.M.
        Eating disorders.
        N Engl J Med. 1985; 313: 295-303
        • King A
        Primary and secondary anorexia nervosa syndromes.
        Br J. Psychiatry. 1963; 109: 470-479
        • Stricker E.M.
        • Andersen A.E.
        The lateral hypothalamic syndrome: comparison with the syndrome of anorexia nervosa.
        Life Sci. 1980; 26: 1927-1933
        • Kamalian N
        • Keesey R.E.
        • Zurhein G.M.
        Lateral hypothalamic demyelination and cachexia in a case of ‘malignant’ multiple sclerosis.
        Neurology. 1975; 25: 25-30
        • Grossman S.P.
        Neurophysiologic aspects: extrahypothalamic factors in the regulation of food intake.
        Adv Psychosom Med. 1972; 7: 49-72
        • Sung D.I.
        Suprasellar tumors in children: a review of clinical manifestations and managements.
        Cancer. 1982; 50: 1420dash15
        • Jennings M.T.
        • Gelman R
        • Hochberg F
        Intracranial germ-cell tumors: natural history and pathogenesis.
        J Neurosurg. 1985; 63: 155-167
        • Lucas A.R.
        Toward the understanding of anorexia nervosa as a disease entity.
        in: 3rd ed. Mayo Clin Proc. 56. 1981: 254-264

      Article info

      Publication history

      Accepted: October 28, 1993
      Received: June 18, 1993

      Identification

      DOI: https://doi.org/10.1016/0387-7604(94)90064-7

      Copyright

      © 1994 Elsevier Science B.V. All rights reserved. Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX